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KMID : 0895820130230020033
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Journal of Oriental Rehabilitation Medicine
2013 Volume.23 No. 2 p.33 ~ p.48
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Effect of Aqueous Extract of Sukjiyanggeun-Tang( ) on Functional Recovery and Expressions of Inflammatory Mediators after Sciatic Nerve Crushed Injury in Rat
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Jang Gun
Song Yun-Kyung
Lim Hyung-Ho
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Abstract
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Objectives : Peripheral nerve injuries are commonly encountered clinical problems and often result in severe functional deficits. Sukjiyanggeun-Tang(shudiyangjin-tang),in oriental medicine, has been used to treat various musculoskeletal disorders.
Methods : In the present study, the effects of aqueous extract of Sukjiyanggeun-Tang(shudiyangjin-tang) on functional recovery, severity of pain, and expressions of neurofilament, cycloxygenease-2(COX-2), inducible nitric oxide synthase(iNOS), and tumor necrosis factor-.(TNF-a) following sciatic crushed nerve injury in rats were investigated. For this study, walking tract analysis, plantar test, western blot analysis for COX-2 iNOS, and TNF-.a and Immunofluorescence test for neurofilament were performed.
Results : In the present results, sciatic functional index(SFI) in walking tract analysis was significantly decreased following sciatic crushed nerve injury, and pain severity in plantar test was significantly increased. COX-2, iNOS and TNF-a expressions were increased whereas neurofilament expression was decreased by sciatic crushed nerve injury, In contrast, treatment with Sukjiyanggeun-Tang(shudiyangjin-tang) improved SFI in walking tract analysis and suppressed the pain severity in sciatic crushed nerve injury. Sukjiyanggeun-Tang(shudiyangjin-tang) treatment also suppressed COX-2, iNOS, and TNF-a expressions and enhanced the neurofilament expression in sciatic crushed nerve injury.
Conclusions : In the present study, we have shown that Sukjiyanggeun-Tang(shudiyangjin-tang) is the effective therapeutic modality to ameliorate the symptoms of sciatic crushed nerve injury.
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KEYWORD
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Sukjiyanggeun-Tang, shudiyangjin-tang, Sciatic nerve injury, Axonal Regeneration, Sciatic functional index, COX-2, iNOS, TNF-a
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